Villain with O
- Ogre
- Otto Octavius
- Octavious
- Osama bin laden
- Octavius
- Odin
- Overlord
- Omni man
- Omega
- Omniman
- Orochimaru
- Oblivion
- OJ Simpson
- Ozymandias
- onceler
- Advertisement
- Otto
- Orion
- Orc
- Obito
- osborn
- Oliver
- Osborne
- Osama
- Orcs
- Ozai
- Octavian
- othello
- Otto octavious
- octoman
- Oracle
- Oberon
- oswald cobblepot
- Oswald
- Ophelia
- Odd Job
- Onslaught
- Obadiah Stane
- Omega red
- orange
- Oddjob
- octo octavius
- Oman
- O'hare
- Oogie Boogie
- Octavio
- Octopus Doctor
- Oger
- Obliterator
- Orange man
- Oculus
- Octavios
- Ogres
- oedipus
- octavia
- Omicron
- Orson
- Oli London
- ock
- oliver twist
- Ocean
- Advertisement
- orpheus
- ozzy
- Omarosa
- OSCAR
- Octane
- owen
- octupus
- Octavias
- orlando
- Ogar
- Ostrich
- Orangutan man
- odile
- orson welles
- Octopi
- Oni
- Outsider
- Oddball
- olive
- Ohio
- Otello
- Osbourne
- Ork
- Om puri
- Owlman
- Opps
- Opal
- Ozark
- Orochi
- Outlander
- Orca
- Otto Von Bismark
- Oligarchs
- Oh no
- oclin
- Omkara
- Ojoker
The words in the list Villain with O come from players of the word game City, Country, River.