Villain with O
- Ogre
- Otto Octavius
- Osama bin laden
- Octavious
- Octavius
- Overlord
- Odin
- Omni man
- Omega
- Omniman
- Oblivion
- Orochimaru
- OJ Simpson
- onceler
- Ozymandias
- Advertisement
- Otto
- Orion
- Otto octavious
- osborn
- Orc
- Oliver
- Obito
- Osama
- Ozai
- Osborne
- Orcs
- othello
- Octavian
- octoman
- Oracle
- Oswald
- Ophelia
- Oberon
- oswald cobblepot
- Odd Job
- Omega red
- Obadiah Stane
- Onslaught
- Oman
- O'hare
- octo octavius
- Oddjob
- orange
- Obliterator
- Orange man
- Oger
- Octavio
- Octopus Doctor
- Oogie Boogie
- Orson
- octavia
- oedipus
- Octavios
- Omicron
- Ogres
- Oculus
- owen
- OSCAR
- Owlman
- Octane
- Advertisement
- Octavias
- octupus
- Omarosa
- ock
- ozzy
- orpheus
- Ocean
- oliver twist
- Oli London
- Ozark
- Orochi
- Owl man
- Om puri
- Osbourne
- Ork
- Otto Octavias
- Opps
- Opal
- Otello
- Otto Von Bismark
- olive
- Ohio
- Orca
- Oddball
- orson welles
- Outsider
- Orangutan man
- orlando
- Ogar
- Ostrich
- Octopi
- Oni
- Outlander
- odile
- Ollie
- Ojoker
- Omkara
- oclin
- Oh no
- Oligarchs
The words in the list Villain with O come from players of the word game City, Country, River.