Villain with S
- Scar
- Sandman
- Satan
- Scarecrow
- Sauron
- Sinestro
- Scarface
- Slenderman
- Salazar Slytherin
- Scorpion
- Skeletor
- Shigaraki
- Stalin
- silver surfer
- Slade
- Sand man
- Shego
- Scrooge
- Slender man
- Shredder
- Sith
- Saruman
- Snoke
- swiper
- Sid
- sand man
- satin
- scarlet witch
- Scream
- Severus snape
- Shadow
- Sephiroth
- sinister
- Spawn
- scorpio
- Slitherin
- scarlett witch
- Sabretooth
- stepmother
- Sasquatch
- Snidely Whiplash
- sal
- sinbad
- Snake
- scaramanga
- snakes
- sindrome
- Storm
- Son of Sam
- sinister six
- serpent
- scar from lion king
- Scrappy Doo
- Subzero
- Syndrom
- Sorcerer
- Savitar
- Step mother
- Spider
- Stromberg
- surtur
- Solomon Grundy
- Snake man
- Starscream
- Spider-Man
- scar face
- spongebob
- snow queen
- Stain
- sarah
- Sinistro
- Stingray
- shark
- Samson
- samba
- Shere Khan
- sabertooth
- Shylock
- snakeman
- Sabertooth
- Storm trooper
- Sara
- Sun
- Spy
- superman's enemy
- Strange
- Smeagol
- Smaug
- Stormtrooper
- Slater
- Steppenwolf
- Sher khan
- Shakuni
- Samara
- Sylas
- Sophia
- Syndrone
- sandy
- Spectre
- Sambha
The words in the list Villain with S come from players of the word game City, Country, River.