Villain with S
- Scar
- Sandman
- Satan
- Scarecrow
- Sauron
- Sinestro
- Scarface
- Slenderman
- Salazar Slytherin
- Scorpion
- Skeletor
- Shigaraki
- Stalin
- silver surfer
- Slade
- Sand man
- Shego
- Slender man
- Scrooge
- Shredder
- Saruman
- Sith
- Snoke
- Sid
- swiper
- sand man
- satin
- Sidious
- scarlet witch
- Scream
- Severus snape
- Shadow
- Sephiroth
- scorpio
- stepmother
- sinister
- Slitherin
- scarlett witch
- Spawn
- Sabretooth
- Sasquatch
- Son of Sam
- sindrome
- snakes
- Snake
- sal
- Snidely Whiplash
- scaramanga
- sinbad
- serpent
- sinister six
- Storm
- Scrappy Doo
- Subzero
- Syndrom
- scar from lion king
- Sorcerer
- Savitar
- Spider
- Step mother
- Stromberg
- spongebob
- scar face
- surtur
- Solomon Grundy
- Snake man
- Spider-Man
- Starscream
- snow queen
- Stingray
- Stain
- shark
- Sinistro
- sarah
- Sabertooth
- Samson
- Shere Khan
- samba
- Smeagol
- sabertooth
- Smaug
- Sun
- Storm trooper
- Spy
- snakeman
- superman's enemy
- Shylock
- Sara
- Strange
- Stormtrooper
- Shakuni
- Sher khan
- Scaramouche
- Sylas
- Sarah Palin
- Steppenwolf
- susan
- Samara
- Sylvester the cat
- Sussy
The words in the list Villain with S come from players of the word game City, Country, River.