Villain with S
- Scar
- Sandman
- Satan
- Scarecrow
- Sauron
- Sinestro
- Scarface
- Slenderman
- Salazar Slytherin
- Scorpion
- Skeletor
- Shigaraki
- Stalin
- silver surfer
- Slade
- Sand man
- Shego
- Slender man
- Scrooge
- Shredder
- Saruman
- Sith
- Snoke
- Sid
- swiper
- sand man
- satin
- Sidious
- scarlet witch
- Scream
- Shadow
- Severus snape
- Sephiroth
- sinister
- stepmother
- Sasquatch
- Slitherin
- Sabretooth
- scarlett witch
- Spawn
- scorpio
- snakes
- sinbad
- sindrome
- Snake
- sal
- Son of Sam
- Snidely Whiplash
- scaramanga
- Storm
- serpent
- sinister six
- Scrappy Doo
- Subzero
- Syndrom
- Sorcerer
- scar from lion king
- Savitar
- Starscream
- surtur
- Solomon Grundy
- Snake man
- spongebob
- Spider-Man
- scar face
- Stromberg
- Spider
- Step mother
- snow queen
- Stain
- Stingray
- sarah
- shark
- Sinistro
- sabertooth
- samba
- Samson
- Shere Khan
- Strange
- Smeagol
- Sun
- Storm trooper
- superman's enemy
- Shylock
- snakeman
- Spy
- Sara
- Smaug
- Sabertooth
- Stormtrooper
- Sher khan
- Shakuni
- Scaramouche
- Steppenwolf
- Spot
- Samara
- susan
- Sith Lord
- Sylvester the cat
- Sirius
The words in the list Villain with S come from players of the word game City, Country, River.