Video Game with Y

• Yakuza

  Real game by Sega (2005), action-adventure brawler.

• Yandere Simulator

  Real indie stealth sim on PC; demo builds since ~2015.

• Yoshi

  Yes! 1991 Nintendo puzzle game for NES/Game Boy.

• Yager
• Yakuza 0

  Yes! 2015/2017 Sega prequel, action-adventure.

• Yoshi's Island

  Yes! 1995 Nintendo platformer (SNES classic).

The words in the list Video Game with Y come from players of the word game City, Country, River.